Critical Determinants of Ca2+-Dependent Inactivation within an EF-Hand Motif of L-Type Ca2+ Channels

By B. Peterson, Joanna S. Lee, J. Mulle, Yan Wang, Marita de Leon, D. T. Yue. 2000

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Computer model of action potential of mouse ventricular myocytes. (2004, methodology): “In Ca(2) channels, the Ca(2) dependence of inactivation is mediated by the highly localized increase of [Ca(2) ] that binds to calmodulin, which is constitutively bound to the Ca(2) channel (74, 75).”
A computational model of the human left-ventricular epicardial myocyte. (2004, background): “Recent experimental data from both isolated myocytes (Linz and Meyer, 1998; Sipido et al., 1995) as well as recombinant channels expressed in HEK293 cells ( Peterson et al., 1999, 2000 ) show that voltage-dependent inactivation of ICaL is slow and incomplete whereas Ca21-mediated inactivation is”
Neuronal voltage-gated calcium channels: structure, function, and dysfunction. (2014, background): “Upon a rise in intracellular calcium, channelanchored CaM binds calcium, which in turn promotes a conformational change in the C terminus/CaM complex and gives rise to CDI (Ben Johny et al., 2013; Erickson et al., 2001, 2003; Peterson et al., 2000) (Figure 2).”