The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability.

By Lauretta M S Chan, S. Lowes, B. Hirst. European Journal of Pharmaceutical Sciences, 2004

608 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Pharmacology

View Paper: https://www.semanticscholar.org/paper/dbda8e153de7e6966b2cd70fcbb63a4aee5dd5ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. D. McClements

In Pediatrics, Perinatology and Child Health

1. W. Charman
2. Christopher J. H. Porter
3. Natalie L. Trevaskis

In Pharmacology

1. W. Charman
2. Christopher J. H. Porter
3. Natalie L. Trevaskis

Citations in the corpus

• A Novel Chemometric Method for the Prediction of Human Oral Bioavailability (2012, background): “As well as the efflux pump, the cellular route of absorption exposes drugs to intracellular metabolic systems; small intestinal enterocytes provide the first site for CYPP450-mediated metabolism of orally ingested drugs and xenobiotics [15].”
• Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs (2007, background): “These transporters most commonly belong to the ATP-binding cassette (ABC) superfamily of proteins, which, as a wider group, comprise membrane transporters, ion channels and receptor”
• Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “MRP3 is also believed to play an important role in the enterohepatic circulation of biles salts (Chandra and Brouwer, 2004).”