Macrophages and therapeutic resistance in cancer
By B. Ruffell, Lisa M. Coussens. Cancer Cell, 2015
1,347 citations recorded by the source corpus.
How neoplastic cells respond to therapy is not solely dependent on the complexity of genomic aberrations they harbor, but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor immune responses holds great potential for improving outcomes and impacting long-term patient survival. Macrophages are key regulators of homeostatic tissue and tumor microenvironments; thus therapeutics impacting macrophage presence and/or bioactivity have shown promise in preclinical models, and are now being evaluated in the clinic. This review discusses the molecular/cellular pathways thus far identified whereby macrophages mediate therapeutic responses.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/dbc925eb0c64df8d81d2d5affe3b1e5e1a082b11
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Citations in the corpus
- Macrophage plasticity, polarization, and function in health and disease (2018, neutral): “…suppress CTLs responses, and activate Tregs (Biswas & Mantovani, 2010; Belgiovine et al., 2016; Chittezhath et al., 2014; Jetten et al., 2014; Ruffell & Coussens, 2015; Sica, Allavena, et al., 2008; Sica et al., 2015; Sica, Larghi, et al., 2008; Sica & Mantovani, 2012; Squadrito & De Palma,…”
- Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment (2017, background): “M2macrophages have been speculated to play a role in resistance to radiotherapy (Meng et al., 2010; Ruffell and Coussens, 2015), and macrophage targeting immunotherapy (Pyonteck et al., 2013; Ries et al., 2014) may play a radiosensitizing role.”
- Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis. (2018, background): “Macrophages, especially M2 macrophages, play dramatically significant roles in tumor initiation and progression, as they can stimulate immune suppression, metastasis, and resistance to anticancer therapy (20, 36, 37).”
- Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, neutral): “TAM2 cells produce VEGF and antiinflammatory molecules, such as IL-10, TGF-β, and arginase 1 (ARG1) (57, 60).”
- Overcoming Endocrine Resistance in Breast Cancer (2020, neutral): “, 2014), and 3) microenvironmental components that affect drug sensitivity (Hirata et al., 2015; Kalluri, 2016; Ruffell and Coussens, 2015; Sahai et al., 2020).”
- The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, methodology): “In clinical trials, several approaches to inhibit CSF-1R are currently being used, including antibodies and small molecules (7, 11, 12).”