Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.
By Michael A. Fischbach, C. Walsh. Chemical Reviews, 2006
1,353 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/db6502a7fa8e377162cbfab1a5ee266730390d6e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Michael A. Fischbach
- Nadine Ziemert
- C. Walsh
- Eric E. Allen
- Jonathan H. Badger
- P. Jensen
- Sheila Podell
- K. Penn
In Pharmacology
- Michael A. Fischbach
- P. Jensen
- Nadine Ziemert
- Jon Clardy
- C. Walsh
- J. Raaijmakers
- I. de Bruijn
- O. Nybroe
Citations in the corpus
- The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity (2012, background): “The molecular architectures of PKS and NRPS genes have been reviewed in detail and minimally consist of activation (AT or A), thiolation (ACP or PCP), and condensation (KS or C) domains, respectively [14,15,16,17,18].”
- New antibiotics from bacterial natural products (2006, background): “The biosynthetic logic of the pantocins differs from that of PKSs and NRPSs, which tether nascent substrates as protein-bound thioester”
- Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics. (2010, background): “NRPSs possess a modular structure and each module is a building block for the stepwise incorporation of an amino acid in the LP peptide moiety (Finking & Marahiel, 2004; Fischbach & Walsh, 2006; Gross & Loper, 2009; Marahiel & Essen, 2009).”