Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2

By M. Goll, F. Kirpekar, K. Maggert, J. Yoder, C. Hsieh, Xiaoyu Zhang, K. Golic, Steven E. Jacobsen, T. Bestor. Science, 2006

1,162 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/db4e2bce17fef760877a6c9a10c9fdb698705d6a

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In Molecular Biology

Citations in the corpus

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA (2012, background): “Secondly, TRDMT1 (tRNA aspartic acid MTase 1, also known as DNMT2), has been shown to methylate position 38 on tRNA in eukaryotes (12,31,32), and tRNA and tRNA in Drosophila (12).”
The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome (2013, background): “This modification arises in a post-replicative enzymatic reaction, when DNA methyltransferase (Dnmt) proteins transfer a methyl group from the cofactor S-adenosyl-L-methionine onto carbon 5 of cytosine in DNA.”
Epigenetics and gene expression (2010, background): “DNMT2 has reportedly only weak DNA methylation ability in vitro and appears to be involved in methylation of RNA (Goll et al., 2006).”
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Active demethylation An indirect, enzyme-catalyzed DNA demethylation mechanism could involve the deamination of 5mC to thymidine by the activation-induced deaminase (AID) or apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC1) (Fig.”
From Molecules to Management: Mechanisms and Consequences of Locust Phase Polyphenism (2017, background): “(Goll et al., 2006) although a dual role in both tRNA and DNAmethylation”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “DNMT2 is a methyltransferase homolog that methylates cytosine-38 in the anticodon loop of aspartic acid transfer RNA instead of DNA.(15) DNMT3A and DNMT3B, in contrast to DNMT1, have preference for unmethylated CpG dinucleotides and perform de novo methylation during development.”
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. (2010, methodology): “Dnmt2 mutant mice, flies, and plants were reported to be viable and fertile (Goll et al. 2006) under standard laboratory conditions.”
Methylation multiplicity and its clinical values in cancer (2021, neutral): “28).”
How do lncRNAs regulate transcription? (2017, background): “DNMT2, the enigmatic DNMT homolog, has little DNAmethylation activity but insteadmethylates transfer RNAs (tRNAs) (103, 104), and this could imply that the RNA binding properties of DNMTs have a deep evolutionary origin.”
Epigenetic modifications and human disease (2010, background): “However, it has been reported that DNMT2 methylates tRNA Asp (ref”