Natural selection shaped regional mtDNA variation in humans

By D. Mishmar, E. Ruiz‐Pesini, P. Golik, V. Macaulay, Andrew G. Clark, S. Hosseini, Marty C. Brandon, Kirk A Easley, E. Chen, Michael D. Brown and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,017 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/db05d354f3527c9afa6f2181e928ec575310966a

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Citations in the corpus

Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups. (2009, methodology): “[35] and 160 kya according to Kivisild et al.”
Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation (2009, background): “back to a common matrilineal ancestor that lived approximately 200,000 years ago in Africa (Behar et al., 2008b; Macaulay et al., 2005; Mishmar et al., 2003).”
The incomplete natural history of mitochondria (2004, background): “Temperature may be an important agent of selection in human and Drosophila mtDNA (Doi et al. 1999; Mishmar et al. 2003).”
METABOLIC ADAPTATION IN INDIGENOUS SIBERIAN POPULATIONS (2005, background): “metabolic rate Canada) were elevated compared to lower latitude populations, as well as nonindigenous populations living in the same regions (e.g., Hart et al. 1962, Heinbecker 1928, Milan et al. 1963, Milan & Evonuk 1967, Rabinowitch & Smith 1936, Rennie et al. 1962, Rodahl 1952).”
Towards the understanding of post-glacial spread of human mitochondrial DNA haplogroups in Europe and beyond: a phylogeographic approach (2004, background): “Recent studies of human populations have compared the ratios of nonsynonymous and synonymous substitutions in different lineages of complete mtDNA sequences from Africa, Asia and Europe (Mishmar et al. 2003; Elson et al. 2004; Ruiz-Pesini et al. 2004).”
Mitochondrial mutations in cancer (2006, background): “…the synonymous tumorspecific somatic mRNA gene mutations encompass five transversions and 40 transitions (Table 3), consistent with the predominance of transition mutations found in inter-specific and intra-specific population studies (Brown et al., 1982; Ingman et al., 2000; Mishmar et al., 2003).”
An enhanced MITOMAP with a global mtDNA mutational phylogeny (2006, background): “Subsequent analysis added haplogroups in Europe (H, I, J, T, U, Uk, V, W and X) (36,37), Asia (many derivatives of macro-haplogroups M and N which radiated out-of-Africa) (38,39) and Africa (haplogroups L0, L1, L2 and L3) (7,40,41).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Regional variation was also observed in multiple ND subunits (148).”
Mitochondrial DNA: more than an evolutionary bystander (2014, background): “A decade ago, environmental temperature was controversially suggested to have an influence in humans (Mishmar et al. 2003).”