Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation

By M. van Oven, M. Kayser. Human Mutation, 2009

1,814 citations recorded by the source corpus.

Human mitochondrial DNA is widely used as tool in many fields including evolutionary anthropology and population history, medical genetics, genetic genealogy, and forensic science. Many applications require detailed knowledge about the phylogenetic relationship of mtDNA variants. Although the phylogenetic resolution of global human mtDNA diversity has greatly improved as a result of increasing sequencing efforts of complete mtDNA genomes, an updated overall mtDNA tree is currently not available. In order to facilitate a better use of known mtDNA variation, we have constructed an updated comprehensive phylogeny of global human mtDNA variation, based on both coding‐ and control region mutations. This complete mtDNA tree includes previously published as well as newly identified haplogroups, is easily navigable, will be continuously and regularly updated in the future, and is online available at http://www.phylotree.org. © 2008 Wiley‐Liss, Inc.

Subfields: Clinical Biochemistry, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/60a61b8075898492176ba307b87e81481112f981

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Vincent Procaccio
2. Dimitra Chalkia

In Genetics

1. Lukas Forer
2. Mannis van Oven

In Molecular Biology

1. Lukas Forer
2. Vincent Procaccio
3. Dimitra Chalkia
4. Mannis van Oven

Citations in the corpus

• mtDNA Variation and Analysis Using MITOMAP and MITOMASTER (2013, methodology): “Haplotyping is based on Phylotree (van Oven and Kayser, 2009) and is generated by Mitomaster using the Haplogrep engine (Kloss-Brandstatter et al., 2011).”
• HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing (2016, methodology): “After changing the version of Phylotree within HaploGrep 2, samples are re-classified automatically and haplogroup updates are listed in brackets, thereby also triggering the rule-based engine and emitting a warning if a sample is classified as belonging to different haplogroups.”
• HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups (2011, background): “Currently, the most comprehensive overview of the human mtDNA tree is reflected in Phylotree (http:// www.phylotree.org), a regularly updated classification tree of global mtDNA variation considering all currently available whole mtDNA genome sequences [van Oven, 2010; van Oven and Kayser, 2008].”