Osteoclast-derived activity in the coupling of bone formation to resorption.

By T. Martin, N. Sims. Trends in Molecular Medicine, 2005

662 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/da9f0effebb2ba8327a40627956611db0b69f69e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Kantarcı
2. R. Baron
3. T. V. Van Dyke
4. Kate Schroder
5. S. Ferrari
6. L. Xing
7. R. Russell
8. T. Martin

In Oncology

1. A. Kantarcı
2. T. V. Van Dyke
3. S. Ferrari
4. L. Xing
5. R. Russell
6. T. Martin
7. L. Raggatt
8. N. Sims

Citations in the corpus

• Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. (2014, background): “On the basis of experiments in mice with inactivating mutations of each of the two alternative signaling pathways of gp130, it was concluded that resorption alone was insufficient to promote coupled bone formation, but that active osteoclasts are the likely source, and that the coupling pathway is I”
• Inflammatory and immune pathways in the pathogenesis of periodontal disease (2014, background): “Before the discovery of RANK, its ligand (RANKL) and its antagonist (osteoprotegerin), the development and the formation of osteoclasts were thought to be controlled by factors produced by osteoblasts and bone marrow stromal cells (162, 198).”
• Biology of RANK, RANKL, and osteoprotegerin (2007, background): “More recently, it has become increasingly clear that osteoclasts are not simply trench digging cells, but that they have important regulatory functions as immunomodulators in pathologic states and that they may also regulate osteoblast function [2].”
• Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1 (2008, background): “Bone remodeling is a highly orchestrated multicellular process that requires the sequential and balanced events of osteoclast-mediated bone resorption and osteoblast-mediated bone formation (38).”
• Denosumab and bisphosphonates: different mechanisms of action and effects. (2011, background): “This balance between catabolic and anabolic functionswithin bone is ensured by the coupling process— an array of cross-talk networks between the osteoclasts and osteoblasts [30,31].”