Denosumab and bisphosphonates: different mechanisms of action and effects.

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Estrogen and the Skeleton (2012, positive): “To date, transforming growth factor beta (TGFβ) has been identified most convincingly as one such “coupling” growth factor (15), but other candidates include insulin-like growth factor I and II (IGF-I and -II), as well as bone morphogenetic proteins (BMPs) (16).”
Bisphosphonates: the first 40 years. (2011, background): “osteoclasts compared with denosumab, which is a fully human antibody that neutralises RANK-ligand (RANKL) [131].”
Breast Cancer Treatment. (2021, background): “47 Metastases to the liver, lung, and brain are common in stage IV breast cancer.”