Interleukin-1 polymorphisms associated with increased risk of gastric cancer

By E. El-Omar, M. Carrington, W. Chow, K. McColl, J. Bream, H. Young, Jesus Herrera, J. Lissowska, Chiu-Chin Yuan, N. Rothman and 4 more. Nature, 2000

2,466 citations recorded by the source corpus.

Subfields: Biomaterials, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/da7e217ead64c3e888e6925740ef75a4748e6726

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. C. Garlanda
5. F. Colotta
6. S. Perwez Hussain
7. F. Bray
8. C. Harris

In Surgery

1. F. Bray
2. A. Mantovani
3. R. Peek
4. Keith T. Wilson
5. E. Kuipers
6. Lydia E. Wroblewski
7. W. Arend
8. C. Garlanda

Citations in the corpus

• Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report (2006, background): “Furthermore, host genetic factors may determine disease outcome 52 The association with H pylori pathogenic factors and host genetic factors is real in Western populations, but the limited strength of the association does not allow a reliable prediction of the outcome at an individual level.”
• Cancer burden in the year 2000. The global picture. (2001, positive): “pylori—a recent study has shown that interleukin-1 gene cluster polymorphisms are associated with an increased risk of gastric cancer [116].”
• The balance between IL-1 and IL-1Ra in disease. (2002, background): “[217] El-Omar EM, Carrington M, Chow W-H, et al.”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “The development of gastritis and gastric tumor have been linked to genetic polymorphisms in the IL-1β gene.(314) An additional mechanism underlying the increased risk of gastric cancer associated with IL-1β is its ability to induce aberrant DNA methylation.”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, result): “pylori-colonized persons with high-expression IL-1 polymorphisms have a significantly increased risk for hypochlorhydria, gastric atrophy, and distal gastric adenocarcinoma compared to that for persons with genotypes that limit IL-1 expression (82).”