The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay

By Hervé Le Hir, D. Gatfield, Elisa Izaurralde, Melissa J. Moore. EMBO Journal, 2001

850 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/da5f2bbf2ed9b45abf7c898dbf8bfcf99ab55b1a

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In Molecular Biology

1. R. Parker
2. O. Isken
3. L. Maquat
4. Nicolas Cougot
5. Bertrand Séraphin
6. S. Babajko
7. A. Yamashita
8. S. Ohno

Citations in the corpus

• Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (2006, background): “In addition, Upf3b is part of the EJC and directly interacts with Y14, a core component of the EJC, in mammals (Kim et al. 2001a; Le Hir et al. 2001; LykkeAndersen et al. 2001).”
• Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “…al. 2000; Kataoka et al. 2000; Lykke-Andersen et al. 2000, 2001; Stutz et al. 2000; Zhou et al. 2000; Ishigaki et al. 2001; Kim et al. 2001a,b; Le Hir et al. 2001a; Rodrigues et al. 2001; Lejeune et al. 2002; Gehring et al. 2003; Bono et al. 2004, 2006; Chan et al. 2004; Chiu et al. 2004; Degot…”
• Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila (2015, neutral): “…and provides a link to processing events downstream from splicing, including nonsense-mediated decay (NMD; encoded by the release factor, Upf1 ) (Le Hir et al. 2001; Kurosaki and Maquat 2013); serine-arginine (SR) splicing factors that although primarily implicated in splicing have also been shown…”
• Circular RNAs: diversity of form and function (2014, background): “The manner by which circRNAs are tagged for export is not yet clear but may involve the deposition of an exon-junction complex during splicing, which could then recruit mRNA export factors (Le Hir et al. 2001).”
• Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “They are also punctuated with exon junction complexes that mark the location of excised introns, thus, playing an important role in the recognition of premature stop codons (Le Hir et al., 2001).”