The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.

By P. Smits, Ping Li, Jennifer R. Mandel, Zhaoping Zhang, Jian-Ming Deng, R. Behringer, B. Crombrugghe, V. Lefebvre. Developmental Cell, 2001

625 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Rheumatology

View Paper: https://www.semanticscholar.org/paper/da23b97b4cb207065d6dc01133ef9aa5a35f41b7

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Citations in the corpus

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. (2002, background): “…hedgehog ( Ihh )- hormone-related peptide ( Pthrp Ihh and Pthrp control the rate of chondrocyte proliferation and the transition of these cells to hypertrophy (Vortkamp et al. 1996); moreover, Ihh coordinates these processes with the onset of osteogenesis in bone collars (St-Jacques et al. 1999).”
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. (2002, background): “In Osx null 1999; Smits et al., 2001). mice, no bone formation occurs.”
Developmental regulation of the growth plate (2003, background): “These phenotypes closely resemble those of mice missing both Sox5 and Sox6, other Sox-family members that cooperate with Sox9 in regulating many chondrocyte gene”
Interactions between Sox9 and β-catenin control chondrocyte differentiation (2004, background): “The severe reduction of cartilage-specific matrix production and lack of proliferating chondrocytes in these mutants is in large part attributable to the absence of Sox5 and Sox6, which themselves are needed for overt chondrocyte differentiation but not mesenchymal condensations (Smits et al. 2001).”
Development of the endochondral skeleton. (2013, background): “Thus, SOX9, SOX5, and SOX6 constitute a trio of transcription factors essential for chondrocyte differentiation.”
Reaching a genetic and molecular understanding of skeletal development. (2002, background): “As a result of this disruption, there is no columnar organization of chondro-and the Fgf pathway is indicated by data showing that either FGF18 or FGFR3 signaling can inhibit Ihh expres- cytes in the growth plate, and endochondral bone formation as a whole is affected (Smits et al., 2001).”
The control of chondrogenesis (2006, background): “L-Sox5 and Sox6 are required for the expression of Col9a1, aggrecan, and link protein, as well as Col2a1, during overt chondrocyte differen- tiation [Smits et al., 2001].”
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. (2005, methodology): “RNA in situ hybridization was performed on paraffin-embedded sections using [35S]-labeled antisense probes as previously described (36).”