The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.
By David K. Rhee, J. Marcelino, M. Baker, Y. Gong, P. Smits, V. Lefebvre, G. Jay, M. Stewart, Hongwei Wang, M. Warman and 1 more. Journal of Clinical Investigation, 2005
626 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology and Allergy, Rheumatology
View Paper: https://www.semanticscholar.org/paper/218ec1212357caed217155d5d512a9bb23cbe784
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In Rheumatology
Citations in the corpus
- The Role of Synovitis in Osteoarthritis pathogenesis (2012, background): “In addition, lubricin reduces pathologic deposition of proteins at the articular surface [82].”
- Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “Prg4 global knockout mice develop aging-related joint disorders with loss of chondrocytes in the superficial zone of articular cartilage and synovial cell hyperplasia.(432) Running and fluid flow shear stress could promote the expression of Prg4 in the superficial zone chondrocytes in vivo and in vi”