Developmental regulation of the growth plate

By H. Kronenberg. Nature, 2003

2,809 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c6a6896ccf24f9adb68164074b6d5a51bb948a6b

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In Molecular Biology

1. R. Jilka
2. Fanxin Long
3. S. Manolagas
4. E. Olson
5. J. Esko
6. J. Richardson
7. G. Karsenty
8. Charles A. O’Brien

Citations in the corpus

• The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone. (2004, background): “…et al., 2004), but the mechanisms for these responses in chondroblasts and chodrocytes involve different mechanical stimuli and molecular pathways (Kronenberg, 2003; Harada and Rodan, 2003; Boyle et al., 2003); the interactions between age and loading in cartilage would merit a review in its own…”
• Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “However, during endochondral ossification, mesenchymal progenitors condense to form chondrocytes (cartilage cells) and perichondrial cells, which ensheath the cartilage primordiu”
• Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. (2004, background): “Indian hedgehog (Ihh) secretion from prehypertrophic chondrocytes tightly controls chondrocyte hypertrophy and differentiation (Vortkamp et al., 1996, Kronenberg, 2003).”
• VEGF as a Key Mediator of Angiogenesis in Cancer (2005, background): “Deletion of a single VEGF allele results in abnormal blood vessel development and lethality in murine embryos. VEGF and angiogenesis are also required for endochondral bone formation [”
• Heparan sulphate proteoglycans fine-tune mammalian physiology (2007, background): “Axial bone growth occurs through growth plates in which chondrocytes undergo a coordinated programme of proliferation, hypertrophy and ossification under the control of Indian hedgehog (IHH), FGF18, BMPs, Wnts and probably other factor”
• Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. (2005, background): “Ihh is a central regulator of skeletogenesis, which among other activities is required for osteoblastogenesis in endochondral, but not membranous, bones (Kronenberg, 2003).”
• Matrix-embedded cells control osteoclast formation (2011, background): “During longitudinal bone growth, calcified cartilage produced by chondrocytes is resorbed by osteoclasts and replaced by a bone matrix made by osteoblasts in a process known as endochondral bone formatio”
• Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors (2006, background): “Clearly, Ihh continues to be expressed postnatally within prehypertrophic chondrocytes, and the upregulation of Ihh signaling at sites of fracture repair implicates Ihh in skeletal homeostasis, repair and regeneration (Vortkamp et al., 1998; van der Eerden et al., 2000; Le et al., 2001).”