Repopulation of cancer cells during therapy: an important cause of treatment failure

By John J. Kim, I. Tannock. Nature Reviews. Cancer, 2005

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Lessons from phase III clinical trials on anti-VEGF therapy for cancer (2006, background): “Whereas none of the successful phase III trials of bevacizumab to date used dose-dens”
Angiogenesis as a therapeutic target (2005, background): “Furthermore, it has been proposed that progressively accelerated proliferation and repopulation of cancer cells during intervals of radiotherapy or chemotherapy is an important cause of treatment failur”
Strategies to improve radiotherapy with targeted drugs (2011, background): “; the ability of the surviving cells to repopulate within a treatment time of 6–7 week”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “Acquired tumor radioresistance can be induced during radiotherapy owing to tumor repopulation [272].”
Drug penetration in solid tumours (2006, background): “, leads to the effective exposure of cells distal from blood vessels (although it seems probable that rapid clearance from plasma limits the amount of drug that penetrates into tumour tissue); second, sequential cycles of doxorubicin-based chemotherapy lead to the sequential killing of cells at incr”