New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning.

By P. Lowary, J. Widom. 1998

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

ACF catalyses chromatosome movements in chromatin fibres (2008, methodology): “et al, 2005), we assembled 12-mer nucleosome and chromatosome arrays on 12-mer repeats of the 601 nucleosome positioning sequence (Lowary and Widom, 1998), using histone octamers and H1 from Drosophila embryos or H5”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “DNA sequences that position nucleosomes far more stably than natural sequences have been engineered, suggesting that nucleosome positioning sequences have evolved to be metastable (Lowary and Widom, 1998; Segal et al., 2006; Henikoff, 2008), allowing modulation of histone-DNA contacts.”
Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions (2014, background): “Eukaryotic nucleosomes bind predominantly to so-called “positioning sequences” and with particular high affinity to the artificial “601” sequence [130].”
MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication (2017, background): “combinant histones and a 147–base pair DNA sequence with highaffinity for histone octamers (Lowary and Widom, 1998).”
Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals (2008, background): “For comparison, also shown are the relative affinities of sequences selected for their relative resistance to nucleosome formation [45] (yellow bars), and of sequences selected for their high nucleosome affinity from the mouse genome [18] (green bars) and from chemically synthesized random sequences”
Organization of Chromatin by Intrinsic and Regulated Phase Separation (2019, background): “DNA sequences phased in TA:AT:TT:AA dinucleotide base pairs position nucleosomes in vitro and in vivo (Kaplan et al., 2009; Lowary and Widom, 1998; Struhl and Segal, 2013).”
Topological polymorphism of nucleosome fibers and folding of chromatin (2021, methodology): “However, in the case of strongly positioned nucleosome ‘‘601’’ selected by Lowary and Widom (53), we are using LNCP 1⁄4 146 bp, in accordance with the crystal structures of this nucleosome core particle (60).”