Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

By A. M. Shapiro, J. Lakey, E. Ryan, G. Korbutt, E. Toth, G. Warnock, N. Kneteman, R. Rajotte. New England Journal of Medicine, 2000

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Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy (2005, methodology): “At the same time, the health of human islet preparations was examined in the cell perifusion system (Wang et al. 1997) and perifusate fractions were assayed for insulin by radioimmunoassay (Brissova et al. 2002).”
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor (2002, background): “This activity, which effectively blocks IL-2 stimulation of lymphocyte division, is the basis for the recent successful clinical use of RAPA to prevent allograft rejection in organ transplantatio”
Tolerance, not immunity, crucially depends on IL-2 (2004, background): “In clinical settings, IL-2R blockade has shown some efficacy at blocking transplant rejection responses and autoimmune diseas”