Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy

By M. Brissova, Michael J Fowler, W. Nicholson, A. Chu, B. Hirshberg, D. Harlan, A. Powers. Journal of Histochemistry and Cytochemistry, 2005

825 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Metabolism Disrupting Chemicals and Metabolic Disorders (2016, neutral): “15 insulin) increases expression of PPARγ and C/EBP proteins and is marked by induction of metabolic genes and adipokines associated with mature adipocytes [124, 125].”
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure (2016, positive): “In particular, mouse islets are organized as a core of beta cells surrounded by non-beta cells (Brissova et al., 2005), whereas, in humans, several patterns have been reported, such as clusters of beta cells within the islets (Orci and Unger, 1975), ribbon-like patterns (Grube and Bohn, 1983), or a…”
Pancreatic β‐cell mass in European subjects with type 2 diabetes (2008, background): “Recent studies focusing on the topography of the different cell types in islets have emphasised that, in contrast to rodent islets, the majority of alpha cells do not form a peripheral rim in normal human islets, but are concentrated in the centre [21–24] in close proximity to vessels [19].”
Pancreas organogenesis: From bud to plexus to gland (2011, background): “Mouse islets comprise 75% b-cells, 20% a-cells, and 5% other endo- crine cells; while human islets contain 50% b-cells, 40% a-cells, 10% dcells, and a few PP cells (Brissova et al., 2005).”