The Mediator complex: a central integrator of transcription

By B. L. Allen, D. Taatjes. Nature reviews. Molecular cell biology, 2015

873 citations recorded by the source corpus.

The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-coding RNA genes and is globally regulated by Mediator — a large, conformationally flexible protein complex with a variable subunit composition (for example, a four-subunit cyclin-dependent kinase 8 module can reversibly associate with it). These biochemical characteristics are fundamentally important for Mediator's ability to control various processes that are important for transcription, including the organization of chromatin architecture and the regulation of Pol II pre-initiation, initiation, re-initiation, pausing and elongation. Although Mediator exists in all eukaryotes, a variety of Mediator functions seem to be specific to metazoans, which is indicative of more diverse regulatory requirements.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d9128cef2a167a5aca31def620d8aa46358509f1

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Citations in the corpus

Transcriptional Addiction in Cancer (2017, positive): “Exemplifying this class of transcriptional signaling proteins are the components of the Mediator complex, which is recruited to enhancer-promoter regions by TFs in the context of transcription activation (Allen and Taatjes, 2015; Kagey et al., 2010).”
YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017, positive): “Mediator can physically bridge enhancer-bound transcription factors and the promoter-bound transcription apparatus (Allen and Taatjes, 2015; Jeronimo et al., 2016; Kagey et al., 2010; Malik and Roeder, 2010; Petrenko et al., 2016).”
Transcriptional Regulation by Nrf2 (2017, background): “The subunit composition of Mediator can change: subunits can be lost or added to affect its biological function (6).”
Regulation of disease-associated gene expression in the 3D genome (2016, neutral): “26 ).”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “As structural changes in proteins caused by cofactor binding or substrate recognition are well known to occur, including in the proteins considered in these examples [56, 57], it can be hypothesized that the functionality of a lncRNA might be ascribed to its ability to function as a cofactor (or eff”
Transcription factors activate genes through the phase separation capacity of their activation domains (2018, background): “Remarkably, hundreds of TFs are thought to interact with the same small set of coactivator complexes, which include Mediator and p300 (Allen and Taatjes, 2015; Avantaggiati et al., 1996; Dai and Markham, 2001; Eckner et al., 1996; Green, 2005; Merika et al., 1998; Oliner et al., 1996; Yin and Wang, ”