YY1 Is a Structural Regulator of Enhancer-Promoter Loops
By A. Weintraub, Charles H. Li, A. V. Zamudio, A. Sigova, N. Hannett, Daniel S. Day, B. Abraham, Malkiel A. Cohen, Behnam Nabet, Dennis L. Buckley and 6 more. Cell, 2017
886 citations recorded by the source corpus.
SUMMARY There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their enhancer elements. Large DNA loops that encompass genes and their regulatory elements depend on CTCF-CTCF interactions, but most enhancer-promoter interactions do not employ this structural protein. Here, we show that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression. We propose that YY1-mediated enhancer-promoter interactions are a general feature of mammalian gene control.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6c4518aea2656c922feac2a0a44407538700a78a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Richard A. Young
- Tong Ihn Lee
- B. Abraham
- N. Hannett
- Charles H. Li
- Denes Hnisz
- James E. Bradner
- Aziz Khan
Citations in the corpus
- Transcription factors activate genes through the phase separation capacity of their activation domains (2018, positive): “2 Cell 175, 1–14, December 13, 2018 endogenous knockin of DNA encoding the FKBP protein fused to OCT4 was induced by addition of dTag for 24 hr (Weintraub et al., 2017) (Figures 2A and S2A).”
- Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III (2020, background): “) [24, 25, 65-71], and noncoding RNAs have been implicated in organizing 3D genome structures, so the 3D genome may likely organize via a combinatory of many factors.”