Cancer associated fibroblasts (CAFs) in tumor microenvironment
By F. Xing, Jamila Saidou, K. Watabe. Frontiers in Bioscience, 2010
645 citations recorded by the source corpus.
Cancer associated fibroblasts (CAFs) is one of the most crucial components of the tumor microenvironment which promotes the growth and invasion of cancer cells by various mechanisms. CAFs demonstrate a high degree of heterogeneity due to their various origins; however, many distinct morphological features and physiological functions of CAFs have been identified. It is becoming clear that the crosstalk between the cancer cells and the CAFs plays a key role in the progression of cancer, and understanding this mutual relationship would eventually enable us to treat cancer patients by targeting CAFs. In this review, we will discuss the latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication of CAFs.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/d891fd040da736117f8e7b7cc2b27e3c67881ed4
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In Molecular Biology
In Oncology
Citations in the corpus
- Tumor angiogenesis: molecular pathways and therapeutic targets (2011, background): “The remodeling response is further driven by recruitment of tumor-associated fibroblasts, which aberrantly deposit extracellular matrix (ECM) proteins and release stimulatory factor”
- Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth (2015, background): “On the other hand, cytokeratin and CD31 are considered negative markers, as CAFs do not have epithelial and endothelial characteristics [19,20].”