Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.

By C. Klebanoff, L. Gattinoni, Parizad Torabi-Parizi, Keith W. Kerstann, A. Cardones, S. Finkelstein, D. Palmer, P. Antony, S. Hwang, S. Rosenberg and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2005

1,032 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c48c26feba8cbefda8b88450da53acd375183906

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Sallusto
2. A. Lanzavecchia
3. N. Restifo
4. E. Wherry
5. Rafi Ahmed
6. S. Kaech
7. C. June
8. Mario Roederer

In Oncology

1. C. June
2. N. Restifo
3. S. Kaech
4. F. Sallusto
5. A. Lanzavecchia
6. M. Jakóbisiak
7. Witold Lasek
8. R. Zagożdżon

Citations in the corpus

• L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “…and favored the formation of Tcm-like cells that have been shown to be superior than effector memory T cells (Tem) in eradicating tumors in mouse models (Klebanoff et al., 2005), we reasoned that increased intracellular L-arginine levels might positively affect anti-tumor T cell responses in vivo.”
• Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo (2015, neutral): “…CD8 + T-cell clones derived from T CM but not T EM provided persistent immunity for more than four years 38,45 ; and TCR-Sommermeyer transgenic T-cells derived from the T N and T CM subsets conferred superior antitumor responses to melanoma than those derived from T EM37,46 .”
• Interleukin 12: still a promising candidate for tumor immunotherapy? (2014, background): “Central memory CD8 T cells have been demonstrated to exert stronger antitumor activity in tumor-bearing mice, as compared with effector memory CD8 T cells [100].”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “A second situation that can dramatically alter memory CD8+ T cell differentiation is persisting infection (Klenerman and Hill, 2005; Wherry and Ahmed, 2004) (Figure 3 and Table 1).”
• Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “Other studies around the same time highlighted the role of TCM cells in tumor control, as they possess high proliferative capacity and are suitable for adoptive T cell transfer, especially when combined with a tumor-antigen vaccination.(17) Accordingly, a recent study highlights the correlation of C”
• Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. (2014, background): “For long-term persistence, some adoptively transferred T cells must also enter secondary lymphoid organs and constantly replenish the pool of circulating T cells that then migrate to tumor sites.(13,28) The Figure 6.”
• Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. (2013, positive): “(46, 47) and chronic viral (48) models have demonstrated that CD8 + T cells with the capacity to home to secondary lymph nodes, where they can be effectively stimulated by professional antigen-presenting cells, are more effective in adoptive immunotherapy.”
• Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. (2008, background): “A prior study attempted to recapitulate in vivo programming of TCM and TEM by a single in vitro stimulation of naive tumor-specific CD8+ T cells from TCR-transgenic mice with antigen and either IL-2 to generate TEM or IL-15 to generate TCM (42).”
• Adoptive immunotherapy for cancer: harnessing the T cell response (2012, neutral): “Farelerde(122,123), insan olmayan primatlarda(124), hümanize edilmiş fare modellerinde(125) hafıza havuzunun içinde (memory pool) TCM hücreleri, TEM hücreleriyle karşılaştırıldığında artmış antitümör aktivite göstermiştir.”
• A human memory T-cell subset with stem cell-like properties (2011, background): “T cell proliferative and survival capacities correlate with the antitumor efficacy of adoptively transferred T cell”