Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
By H. Hosoda, M. Kojima, H. Matsuo, K. Kangawa. Biochemical and Biophysical Research Communications - BBRC, 2000
947 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/d8136330416be7cc24255cc5e96351e15cc35299
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In Endocrine and Autonomic Systems
In Nutrition and Dietetics
In Physiology
Citations in the corpus
- Ghrelin: structure and function. (2005, methodology): “To measure the plasma concentration of ghrelin, it is necessary to use EDTA and aprotinin when collecting blood samples (106, 107).”
- Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. (2001, methodology): “The ligand was radioiodinated using lactoperoxidase methods (16).”
- Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “…sites without immediate access to the blood–brain barrier comes from the observations of ghrelin-producing central neurons (Kojima et al., 1999; Hosoda et al., 2000; Tomasetto et al., 2000; Horvath et al., 2001; Lu et al., 2002; Volante et al., 2002; Cowley et al., 2003; Van Der Lely et al.,…”
- Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. (2002, methodology): “Two ghrelinspecific RIAs have been established; one recognizes the octanoyl-modified portion and another the C-terminal portion of ghrelin (17).”
- Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT (2002, background): “Ghrelin and des-acyl ghrelin are active in vitro even at subnanomolar concentration, whereas their total serum concentration in the rat is 0.22 0.07 nM (Hosoda et al., 2000).”
- Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. (2001, methodology): “In contrast, ghrelin peptide and its specific binding sites are detected in a variety of tissues including the heart and blood vessels (8, 10, 12).”
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “than the acylated form (131), does not displace radiolabeled”