Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
By D. Walther, J. Peter, S. Bashammakh, H. Hörtnagl, M. Voits, H. Fink, M. Bader. Science, 2003
1,591 citations recorded by the source corpus.
Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Clinical Psychology
View Paper: https://www.semanticscholar.org/paper/d7c3e3e8bf20c7cd616323091d50994e38e5ebcb
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In Biological Psychiatry
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Citations in the corpus
- Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis (2015, positive): “In addition, two different isoenzymes of tryptophan hydroxylase (Tph), Tph1 and Tph2, mediate non-neuronal versus neuronal 5-HT biosynthesis (Walther et al., 2003), but little is known regarding the endogenous signals that regulate Tph expression and activity.”
- Candidate gene studies of ADHD: a meta-analytic review (2009, neutral): “brain (Walther et al. 2003).”
- Gene–environment interaction analysis of serotonin system markers with adolescent depression (2004, background): “40 Nevertheless, given the currently available evidence, this situation may not be the case in humans as the reported sequence of cDNA derived from the human brain is from the TPH1 gene rather than the TPH2 gene”
- The developmental role of serotonin: news from mouse molecular genetics (2003, background): “cgi?l=216343">Tph2 ), which is highly homologous to Tph1, but which is the only isoform expressed in the raphe neuron”
- Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “5-HT is also produced by a second isoform, TPH2, in the myenteric plexus; however, this represents a much smaller fraction of total 5-HT (4, 5).”
- Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem (2009, positive): “RESULTS Low Bone Mass in Mice Deprived of Serotonin in the Brain Serotonin synthesis is initiated by hydroxylation of tryptophan, a rate-limiting reaction performed by the enzyme tryptophan hydroxylase 2 (Tph2) in the brain (Walther et al., 2003).”