Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus.
By D. Nathan, J. Lachin, P. Cleary, T. Orchard, D. Brillon, J. Backlund, D. O'leary, S. Genuth. New England Journal of Medicine, 2003
859 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Genetics
View Paper: https://www.semanticscholar.org/paper/d7a2e526e0a9c559830991dce4c958b68a642922
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In Cardiology and Cardiovascular Medicine
In Genetics
Citations in the corpus
- Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. (2005, neutral): “5%) (46) Data from the EDIC study (47,48) suggest that 4–7 years of intensified management may have prolonged beneficial effects (49).”
- The endothelial glycocalyx: composition, functions, and visualization (2007, background): “One of the hallmarks of diabetes is insulin absence or resistance and subsequent hyperglycemia, impairing the protective capacity of the vessel wall [73], and resulting in enhanced endothelial permeability [1] and impaired NO synthase function [20].”
- Meta-Analysis: Glycosylated Hemoglobin and Cardiovascular Disease in Diabetes Mellitus (2004, background): “Of note, a recent study in persons with type 1 diabetes showed that intensive glucose-lowering slows the progression of atherosclerosis (71).”
- Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. (2004, positive): “The update in 2003 from the DCCT and Epidemiology of Diabetes Interventions and Complications Research Group indicated that subjects treated early by intensive glycemic control displayed smaller carotid intima-media thickness than those treated with standard therapies.(7) Several other reports also ”
- Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. (2006, background): “Hyperglycemia itself has been shown to induce a wide array of downstream effects that adversely affect the protective capacity of the vessel wall (2).”