Polyketide biosynthesis: a millennium review.

By J. Staunton, K. Weissman. Natural product reports (Print), 2001

1,484 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d74f3f042acd2f700d3a702a4a030664dc6c445a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Peer Bork
2. Ivica Letunic
3. Tobias Doerks
4. Michael A. Fischbach
5. Christopher J. Creevey
6. Marnix H. Medema
7. Konrad U. Foerstner
8. Anja Doerks

In Organic Chemistry

1. D. Enders
2. Cindy Wang
3. S. Dharmaraj
4. G. Besra
5. K. Takayama
6. M. Jeanty
7. Jon Clardy
8. Christoph Grondal

In Pharmacology

1. Michael A. Fischbach
2. Marnix H. Medema
3. Eriko Takano
4. Ivica Letunic
5. Peer Bork
6. Cindy Wang
7. S. Dharmaraj
8. G. Besra

Citations in the corpus

• Organocatalytic cascade reactions as a new tool in total synthesis. (2010, background): “The blueprints of biosynthesis are based on some key elements, namely cascade reaction sequences and the avoidance of protecting-group strategies, which, when put together, have a tremendous impact on the efficiency of biosynthesi”
• Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis (2005, methodology): “This is a new concept, taken from the type II polyketide synthase systems as models (97).”
• Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. (2014, background): “…set of enzymes for biosynthesis of two deoxysugars, D-desosamine and L-mycarose, that are appended to the polyketide aglycone (Oliynyk et al., 2007; Staunton and Weissman, 2001), while BGCs for glycopeptide antibiotics contain enzymes to synthesize the nonproteinogenic amino acids…”
• Cyanobacterial peptides - nature's own combinatorial biosynthesis. (2006, background): “Cyanobacterial secondary metabolites represent a vast diversity of structures (Moore, 1996; Burja et al., 2001; Staunton & Weissman, 2001; Harrigan & Goetz, 2002) isolated from a variety of taxa and geographic origins.”
• A Computational Screen for Type I Polyketide Synthases in Metagenomics Shotgun Data (2008, background): “Polyketides in general can act among other functions as antibiotics, immunosuppressants, pigments but also as toxins or carcinogens [7] via different mechanisms.”
• Methanotrophs and copper. (2010, neutral): “…including: (1) ribosomal peptide (RP) synthesis; (2) nonribosomal peptide (NRP) synthesis; (3) nonribosomal-independent siderophore (NIS) biosynthesis pathway; and (4) polyketide biosynthesis pathway (Staunton & Weissman, 2001; Challis, 2005; Walsh & Nolan, 2008; McIntosh et al., 2009).”
• SMART 6: recent updates and new developments (2008, background): “This protein family synthesizes a highly diverse group of secondary metabolites that cover many biological functions and have considerable medical relevance (5).”
• Marine Streptomyces as a novel source of bioactive substances (2010, background): “Polyketides are a large and structurally diverse group of natural products synthesised by multifunctional or monoor bi-functional enzymes called polyketide synthases (PKSs) by repetitive condensations of small carboxylic acid units in a manner similar to fatty acid synthesis ( Staunton and Weissman ”