Multiple layers of B cell memory with different effector functions

By I. Dogan, B. Bertocci, Valérie Vilmont, F. Delbos, Jérôme Mégret, S. Storck, C. Reynaud, J. Weill. Nature Immunology, 2009

649 citations recorded by the source corpus.

Subfields: Immunology

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GERMINAL CENTER B CELL DYNAMICS (2016, positive): “In these structures, B cells compete for an array of signals that are delivered in an affinity-dependent manner, so that B cells with higher-affinity B cell receptors (BCRs, the complex formed by surface immunoglobulin [sIg] and the Iga and Igb co-receptors) are expected to progressively outcompete ”
From Vaccines to Memory and Back (2010, positive): “The duration of the germinal center reaction may vary depending on the nature of the antigen and may last for several weeks or months, implying that high affinity antibodies and memory cells can be generated well after elimination of the pathogen (Dogan et al., 2009b).”
A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications (2020, background): “These subtypes were also distinctive in their use of IgM BCRs, which in normal B cells promote proliferation rather than differentiation (Dogan et al., 2009).”
Somatically hypermutated Plasmodium-specific IgM+ memory B cells are rapid, plastic, early responders upon malaria rechallenge (2016, background): “Some studies have demonstrated that unswitchedMBCs preferentially enter GCs while switched MBCs preferentially form plasmablasts (Benson et al., 2009; Dogan et al., 2009; Pape et al., 2011; Seifert et al., 2015).”