Refinement and standardization of synthetic biological parts and devices

By B. Canton, A. Labno, Drew Endy. Nature Biotechnology, 2008

803 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d66ae83129454f7fcdf994538364a56b134759a3

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Citations in the corpus

Directed evolution: new parts and optimized function (2009, background): “To rationalize the time-consuming, ad hoc construction of new biological systems [1], some researchers advocate efforts to ‘standardize’ biological parts in such a way that their behavior in novel assemblies or environments becomes more predictable [2].”
A Modular Cloning System for Standardized Assembly of Multigene Constructs (2011, methodology): “An impressive example is the widely used standard proposed by the BioBrick foundation [10,19].”
Genetic programs constructed from layered logic gates in single cells (2012, background): “Second, the inputs and outputs of the gate should have a common signal carrier that enables them to be layered (the output of one serves as the input to the next) 8 .”
A Synthetic Genetic Edge Detection Program (2009, background): “Living cells can be programmed with genetic parts, such as promoters, transcription factors and metabolic genes (Andrianantoandro et al., 2006; Benner and Sismour, 2005; Canton et al., 2008; Endy, 2005; Haseltine and Arnold, 2007).”
Pretrained AI Models: Performativity, Mobility, and Change (2019, background): “Indeed, there is as yet, no compositional calculus for the properties of AI models, like there is in cryptography [53]; unlike other part sheets [14], proposed AI documentation does not even indicate how to put pieces from a library together to build more complicated AI services (in sociotechnical s”
Design, construction and characterization of a set of insulated bacterial promoters (2010, background): “Achieving proper steady-state protein levels can be accomplished using libraries of constitutive promoters as described here, or by using promoters whose activity can be titrated using a small-molecule inducer (13,45).”
Biomolecular computing systems: principles, progress and potential (2012, methodology): “Thus, automated procedures have been proposed to translate abstract computations to molecular circuits using these components, using theoretical models and experimental measurements of these components in isolation 88,135–137 .”
The Standard European Vector Architecture (SEVA): a coherent platform for the analysis and deployment of complex prokaryotic phenotypes (2012, background): “However, the biological functions and devices that are necessary for such engineering may not be characterized to a point that makes them usable and predictable (2).”
The second wave of synthetic biology: from modules to systems (2009, background): “We now have a growing library of parts ( Table 1 ) and modules that have been verified and characterized in different cellular context”