The second wave of synthetic biology: from modules to systems

By Priscilla E. M. Purnick, Ron Weiss. Nature reviews. Molecular cell biology, 2009

1,238 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f8b0b312a9853ce81eb2e2bd0b9f7ec90526fd49

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Citations in the corpus

Programming an in vitro DNA oscillator using a molecular networking strategy (2011, positive): “This would open the unexplored territory of large synthetic networks, displaying complex dynamic functions (Purnick and Weiss, 2009).”
Dynamic DNA nanotechnology using strand-displacement reactions. (2011, neutral): “[13] Purnick, P.”
Adaptive laboratory evolution – principles and applications for biotechnology (2013, background): “Synthetic biology is a new emerging field [10,11] and systems metabolic engineering has proven very successful for the design and implementation of biotechnological production processes [12-14].”
Genetic programs constructed from layered logic gates in single cells (2012, background): “In practice, the size of programs has been limited to a few circuits 1, 7 .”
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors (2016, background): “Because of the highly modular nature of transcriptional regulatory components, many synthetic biology efforts in the last decade have focused on engineering very sophisticated transcriptional circuits (Purnick and Weiss, 2009).”
Biological underpinnings for lifelong learning machines (2022, background): “Recent data have revealed important commonalities in how information is processed in body-wide neural networks and within single cell pathway networks, which is beginning to be exploited in synthetic biology 141 .”
RNA-Guided Human Genome Engineering via Cas9 (2013, background): “We expect that RNA-guided genome targeting will have broad implications for synthetic biology (22, 23), the direct and multiplexed perturbation of gene networks (13, 24), and targeted ex vivo (25-27) and in vivo gene therapy (28).”
Genetic circuit design automation (2016, background): “Our largest circuit has 12 regulated promoters, doubling a plateau first noted in 2009 regarding a limit on the complexity of circuits that could be designed by hand ( 38 ).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, neutral): “The bottom-up approach is also likely to enrich synthetic biology [2046, 2047, 2048, 2049, 2050, 2051, 2052, 2053].”
Genomic Mining of Prokaryotic Repressors for Orthogonal Logic Gates (2013, background): “To date, the complexity of circuits has been low, consisting of the few available gates based on the same transcription factors re-used across labs and projects 5 .”
The ribosome binding site calculator. (2011, background): “Genetic circuits have been engineered to exhibit bistability, oscillations, pattern formation, traveling waves, and Boolean logic (Danino et al., 2010; Ellis et al., 2009; Khalil and Collins, 2010; Lu et al., 2009; Purnick and Weiss, 2009; Stricker et al., 2008; Tabor et al., 2009).”