Translational research: Crossing the valley of death

By D. Butler. Nature, 2008

650 citations recorded by the source corpus.

Subfields: Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/d64834abe2cf1b273286b0082690c6ea2ba21438

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Public Health, Environmental and Occupational Health

1. V. Subbiah
2. Laura J. Damschroder

Citations in the corpus

• Surgical data science – from concepts toward clinical translation (2020, background): “The process of clinical translation from bench to bedside has been described as a valley of death, not only for surgical (software) products, but biomedical research in general (Butler, 2008).”
• Clarity out of chaos: Use of theory in implementation research. (2020, background): “This scientific discipline was born out of recognition of the proverbial “valley of death” that characterizes the chasm between evidence-based scientific discoveries and the patients who need them (Butler, 2008).”
• The next generation of evidence-based medicine (2023, positive): “In particular, the attrition rate for early-stage developmental therapeutics is quite high, as more than two-thirds of compounds succumb in the ‘valley of death’ between bench and bedside 1,2 .”