Cancer Chemopreventive Activity of Resveratrol

By K. Bhat, J. Pezzuto. Drugs under experimental and clinical research, 2002

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Reactive oxygen species in tumor progression. (2005, background): “At the cellular level, resveratrol regulates apoptosis and induces a cell cycle delay or accumulation of cells in S and G2 phase (193-195).”
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects (2016, background): “Despite their abundance in grapes and wine, resveratrol and pterostilbene are poorly bioavailable, mainly owing to their rapid metabolism and excretion [114,116].”
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS (2004, background): “…is a dietary antioxidant polyphenol, found in grapes, red wine, and peanuts, that has been strongly indicated to have protective effects against cardiovascular disease and, in particular, cancer, including all stages of carcinogenesis (Jang et al., 1997; Bhat and Pezzuto, 2002; Pervaiz, 2003).”
Polyphenols, dietary sources and bioavailability. (2007, background): “the fresh skin of red grapes is particularly rich in resveratrol (50-100 g/kg net weight) [57] which contributes to a relatively high concentration of resveratrol in red wine and grape juice (up to 7 mg aglycones/L and 15 mg glycosides/L in red wine) [58, 59].”