Autophagy and Metabolism
By J. Schneider, C. Sanchez. 2016
642 citations recorded by the source corpus.
Subfields: Epidemiology
View Paper: https://www.semanticscholar.org/paper/d6342210a1753944604af8e4aa14344a8f789155
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- Guido Kroemer
- Beth Levine
- L. Galluzzi
- Alec C. Kimmelman
- E. White
- P. Codogno
- D. Rubinsztein
- N. Mizushima
Citations in the corpus
- Regulation of mTORC1 by amino acids (2014, positive): “To stimulate cell growth, mTORC1 relies on its downstream effectors to coordinately promote anabolic programs such as mRNA translation (10) and repress catabolic programs such as autophagy (11), thereby avoiding a futile cycle of uncoordinated synthesis and degradation.”
- Autophagy and Tumor Metabolism (2017, background): “Given the diverse substrates that can be degraded via autophagy, it is not surprising that autophagy has the potential to fuel nearly all aspects of central carbon metabolism (Guo and White, 2017; Rabinowitz and White, 2010) (Figure 1).”
- Recent insights into the function of autophagy in cancer (2016, background): “Degradative enzymes, contributed by lysosomes, break down the cargo, and the products are exported into the cytoplasm,where they are recycled intometabolic and biosynthetic pathways (Rabinowitz and White 2010; Guo et al. 2016).”
- KRAS: feeding pancreatic cancer proliferation (2014, neutral): “Autophagy is a highly conserved mechanism to degrade intracellular components and promote programmed survival of cells under metabolic stress by providing energy in the form of ATP and building blocks such as amino acids, lipids, sugars and nucleosides [54].”
- Autophagy in malignant transformation and cancer progression (2015, positive): “The degradation products of the autophagosomal cargo, which includes sugars, nucleosides/nucleotides, amino acids and fatty acids, can be transported back to the cytoplasm and presumably re-enter cellular metabolism (Fig 1) (Rabinowitz & White, 2010; Galluzzi et al , 2013).”
- Autophagy, Metabolism, and Cancer (2015, positive): “Mechanisms of tumor promotion Autophagy promotes survival in starvation by recycling intracellular components, and this function is conserved from yeast to mammals (2).”