Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome.

By M. Rajilić-Stojanović, E. Biagi, H. Heilig, K. Kajander, R. Kekkonen, S. Tims, W. D. de Vos. Gastroenterology, 2011

1,012 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ac48e34975d433d4b60bce65948d932123f42c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. J. Foster
6. L. Rinaman
7. S. Duncan
8. M. Simrén

In Infectious Diseases

1. M. Rajilić-Stojanović
2. Antonio Gasbarrini
3. Ted G. Dinan
4. Herbert Tilg
5. G. Clarke
6. W. D. de Vos
7. J. Cryan

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. J. Foster
6. W. D. de Vos
7. L. Rinaman
8. M. Rajilić-Stojanović

Citations in the corpus

• The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “Several studies of the microbiota of irritable bowel syndrome patients and controls have shown that organisms related to these misclassified Ruminococcus spp. are significantly elevated in patients (Kassinen et al., 2007; Rajili c-Stojanovi c et al., 2011; Saulnier et al., 2011).”
• European consensus conference on faecal microbiota transplantation in clinical practice (2017, background): “48 It is plausible that ethanol, beyond killing pathogens, can also severely alter the composition of commensal microbiota, possibly eliminating critical elements such as bacterio-phages, fungi and non-sporulating bacterial components.”
• Faecalibacterium prausnitzii and human intestinal health. (2013, background): “Irritable bowel syndrome (IBS) The intestinal microbiota of IBS patients differed significantly from that of healthy subjects with a twofold increased in the Firmicutes to Bacteroidetes ratio [27].”
• Blautia—a new functional genus with potential probiotic properties? (2021, background): “However, higher abundance of Blautia was found in the fecal microbiota of irritable bowel syndrome and ulcerative colitis patients compared with healthy individuals.(121,122) A greater abundance of Blautia has also been reported in early breast cancer patients with increasing clinical stage and tiss”
• Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, result): “Interestingly, a recent study demonstrated that faecal microbiota of IBS patients could be grouped in a cluster which was completely different from that of healthy controls.(114) Nonetheless, results to date are inconsistent and sometimes contradictory (table 3).”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “It is evident that the gut microbiota is required for the normal development of the hypothalamic pituitary adrenal (HPA) axis and that there is a certain period in early life when colonization must occur to ensure normal development of this critical stress signaling pathway (Sudo et al., 2004;…”
• Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children (2013, background): “paludivivens, was reduced in autistic subjects (Figure 3) but not in IBS patients [66].”
• Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “[133] and decreased levels of Bifidobacteria spp.”
• Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent (2013, background): “Intestinal disorders, such as inflammatory bowel diseases [22-25], irritable bowel syndrome [26], colorectal cancer [27,28] and obesity [29] have all been reported to be associated with a diminished prevalence and abundance of F.”
• Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “Bifidobacterium was one genus of strictly anaerobic gram-positive Actinobacteria whose numbers were markedly decreased (16–47%) in patients diagnosed with IBS-M, IBS-D, or IBS-C relative to healthy controls [177].”
• Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics (2017, background): “, 2014, 2016) and studies reporting lower numbers in IBS patients of alternating type (Rajilic-Stojanovic et al., 2011) have also been published.”
• Stress & the gut-brain axis: Regulation by the microbiome (2017, background): “with increased ratios of Firmicutes to Bacteroidete s at the phylum level [151, 152] (for review see [153]).”