The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes.
By Walter Nickel. European Journal of Biochemistry, 2003
612 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d5c7c17905b25b568c10cb1b9a47d45faed3d149
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In Cell Biology
In Molecular Biology
- Burkhard Rost
- Rajesh Nair
- Søren Brunak
- Piero Fariselli
- Pier Luigi Martelli
- Jannick Dyrløv Bendtsen
- G. von Heijne
- Rita Casadio
Citations in the corpus
- Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates (2005, background): “However, the secretion of proteins that lack signal sequence has been observed for more than a decade (Nickel, 2003).”
- Non-classical protein secretion in bacteria (2005, background): “A number of mammalian sequences are known to be nonclassically secreted [48].”
- α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma (2003, background): “Finally, although we believe that the existence of the two di-acidic motifs on the C-terminal tail of α-syn suggest passage through the ER and Golgi, we cannot exclude the possibility that α-syn is secreted via a nonclassical mechanism, such as endosomal recycling or via exosomes (34).”
- Mimicking cellular sorting improves prediction of subcellular localization. (2005, background): “they do not possess N-terminal signal peptides.(38,39) Furthermore, a particular problem for methods detecting N-terminal signals is that start codons are predicted with less than 70% accuracy by genome projects.”
- Feature-based prediction of non-classical and leaderless protein secretion. (2004, background): “Only FGF1 and FGF2 of this large family are secreted by non-classical means (Nickel, 2003).”
- BaCelLo: a balanced subcellular localization predictor (2006, background): “However some proteins get secreted by means of a non-classical way and do not require N-terminal signal peptides (Nickel, 2003; Bendtsen et al ., 2004).”
- HMGB1: Endogenous Danger Signaling (2008, background): “However, HMGB1 localizes in secretory lysosomes when hyper-acetylated on lysine residues and then is released upon appropriate signaling stimuli (21,28).”