α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
By O. El‐Agnaf, Sultan A. Salem, K. Paleologou, Leanne J. Cooper, N. Fullwood, Mark J. Gibson, M. Curran, J. Court, D. Mann, S. Ikeda and 3 more. The FASEB Journal, 2003
619 citations recorded by the source corpus.
Subfields: Cell Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/2a5fd5532685cd9de12d9b42b9a26b0fc141933f
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Citations in the corpus
- α-Synuclein in Parkinson's disease. (2012, background): “In contrast, oligomeric a-synuclein, measured by a specific ELISA method, was higher in PD compared Cite this article as Cold Spring Harb Perspect Med 2012;4:a009399 13 w w w .p er sp ec ti ve si n m ed ic in e. o rg with control CSF (Tokuda et al. 2010), extending previous findings of identificatio”
- Role of Oxidative Stress in Parkinson's Disease (2013, background): “Although mostly intracellular, a fraction of α-synuclein fibril is released from neurons [41], and α-synuclein is found in the cerebrospinal fluid from PD patients and normal subjects [42], and in human plasma [43].”
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission (2011, background): “While alpha-synuclein is predominantly a cytosolic protein associated with dopamine metabolism, extracellular alpha-synuclein has been observed in CSF and plasma in humans (Borghi et al., 2000; El-Agnaf et al., 2003).”
- Detection of oligomeric forms of α‐synuclein protein in human plasma as a potential biomarker for Parkinson's disease (2006, methodology): “We recently reported the detection of -syn in human plasma, postmortem CSF, and conditioned medium of neuronal cell cultures by immunoprecipitation followed by sodium dodecyl sulfate PAGE (SDS-PAGE) and Western blot methods (14).”
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. (2011, neutral): “Additionally, α -syn monomers and aggregates can be released from cultured cells by exocytosis (20, 23) and exosomes have been suggested to participate in this process (24).”
- Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival (2010, background): “Importantly, the levels of secreted -synuclein (2–12 nM) in our cell system were similar to those reported in biological fluids (Borghi et al., 2000; El-Agnaf et al., 2003).”
- Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates (2005, background): “This concept was challenged recently by the findings that -syn is present in human CSF and blood plasma at low nanomolar concentrations in both PD and normal human subjects (Borghi et al., 2000; El-Agnaf et al., 2003).”