Multifaceted roles of glycolytic enzymes.

By Jung-whan Kim, C. V. Dang. TIBS -Trends in Biochemical Sciences. Regular ed, 2005

702 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d5c519c11c109e667e3339ca9a36fc87b92dd06a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. C. V. Dang
2. Ping Gao
3. J. Pouysségur
4. J. Chiche
5. M. Brahimi-Horn
6. E. Michelakis
7. John R. Mackey
8. Jung-whan Kim

In Molecular Biology

1. C. V. Dang
2. Ping Gao
3. G. Semenza
4. J. Chiche
5. M. Brahimi-Horn
6. J. Pouysségur
7. Jung-whan Kim
8. E. Michelakis

Citations in the corpus

• Overexpression of a cytosolic glyceraldehyde-3-phosphate dehydrogenase gene OsGAPC3 confers salt tolerance in rice (2011, background): “…R.-J. Li Y.-T. Lu (&) State Key Laboratory of Hybrid Rice and Key Lab of MOE for Plant Developmental Biology, College of Life Sciences, Wuhan University, 430072 Wuhan, China e-mail: yingtlu@whu.edu.cn functions in addition to their roles in the glycolytic pathway (reviewed in Kim and Dang 2005).”
• Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “In addition, oncogenes such as Myc and the activation of the PI3K pathway also contribute to HIF1 accumulation and thus promote aerobic glycolysis by induction of HK2, LDH-A and PDK1 [121].”
• Mitochondrial tumour suppressors: a genetic and biochemical update (2005, background): “Once induced, glycolytic enzymes could regulate other cellular processes that include the blocking of apoptosi”
• Metabolic Modulation of Glioblastoma with Dichloroacetate (2010, background): “For example, most glycolytic enzymes also have direct antiapoptotic actions (12); lactic acid promotes angiogenesis and interstitial matrix breakdown, facilitating metastasis (11); and decreased mitochondrial function is associated with inhibition of mitochondriadependent apoptosis (3).”
• Tumor glycolysis as a target for cancer therapy: progress and prospects (2013, unknown): “tional regulation and phosphorylation of histones [42].”
• The interplay between MYC and HIF in cancer (2008, background): “It should be noted that increased levels of glycolytic enzymes resulting from the Warburg effect could also contribute to tumour adaptation through alternative non-glycolytic functions of these enzyme”
• Cancer's molecular sweet tooth and the Warburg effect. (2006, background): “glycolytic enzyme genes and directly binds numerous glycolytic genes, including those encoding HK2, enolase, and LDHA (4).”
• Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer (2008, background): “Several of the enzymes involved in glycolysis are also important regulators of apoptosis and gene transcription, suggesting that links between metabolic sensors, cell death and gene transcription are established directly through the enzymes that control metabolism (Kim and Dang, 2005).”
• A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. (2007, background): “Many glycolytic enzymes have been recognized to also regulate apoptosis, and several oncoproteins induce the expression of glycolytic enzymes (Kim and Dang, 2005).”