Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

By M. Lisby, J. Barlow, R. Burgess, Rodney Rothstein. Cell, 2004

976 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d5a7f2c9f34e5b98693510d02fef22cc76bc5c66

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Citations in the corpus

• Surviving the breakup: the DNA damage checkpoint. (2006, background): “Deletion of Sae2 or elimination of Mre11’s nuclease activity results in the persistence of Mre11-GFP foci at DSBs in vivo as well as a prolongation of the DNA damage checkpoint (8, 24, 82).”
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, methodology): “…of the cell cycle stage, focus formation by others—including CtIP, RPA, ATRIP–ATR, BRCA1, and RAD51—takes place effectively only in association with ssDNA formation by DNA end resection in S/G2 cells (Lisby et al. 2004; Bekker-Jensen et al. 2006; Jazayeri et al. 2006; Sartori et al. 2007).”
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double strand break ends (2008, positive): “Furthermore, MRX is recruited to unprocessed DSB ends, maintained at the break only for a short time immediately after DSB induction, and cannot be detected by ChIP further away from DSBs (Lisby et al., 2004; Shroff et al., 2004).”
• Regulation of homologous recombination in eukaryotes (2010, background): “In yeast, the Rad51 paralog complex consisting of Rad55 and Rad57 facilitates the formation or stabilization of Rad51 filaments (97, 147).”
• Homologous recombination and its regulation (2012, background): “In line with this idea, Rad52 recruitment is dependent upon RPA during S and G2/M phases, and CDK1 activity (20,125).”
• Repair of strand breaks by homologous recombination. (2013, background): “It is also the first protein recruited to a site-specific DSB (Lisby et al. 2004).”