Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

By Yoshitaka Tanaka, G. Guhde, Anke Suter, E. Eskelinen, D. Hartmann, R. Lüllmann-Rauch, P. Janssen, Judith Blanz, K. Figura, P. Saftig. Nature, 2000

931 citations recorded by the source corpus.

Subfields: Epidemiology, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/d55763cb83260544f98c4c965577eecc65ee7c47

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. I. Slaninová
5. Guido Kroemer
6. T. Yoshimori
7. Y. Ohsumi
8. M. Komatsu

In Pathology and Forensic Medicine

1. Douglas R. Green
2. E. Eskelinen
3. P. Saftig
4. P. Boya
5. Guido Kroemer
6. F. Janku

In Physiology

1. N. Mizushima
2. Beth Levine
3. I. Slaninová
4. Guido Kroemer
5. Douglas R. Green
6. P. Codogno
7. P. Boya
8. P. Saftig

Citations in the corpus

• Subversion of Cellular Autophagosomal Machinery by RNA Viruses (2005, background): “As maturation proceeds, the late autophagosome acquires LAMP1 before lysosomal fusion [16, 25, 27, 28] , which defines the ''mature autolysosome.'' Mature autolysosomes are no longer surrounded by double membranes and, having degraded the inner membrane and much of the cytosolic contents, become ele”
• Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease) (2000, result): “From these results and the finding that LAMP-2-deficient mice manifest a similar vacuolar cardioskeletal myopathy, we conclude that primary LAMP-2 deficiency is the cause of Danon diseas”
• Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy* (2012, background): “Severe consequences can result from the inability of a cell to remove damaged and dysfunctional organelles through the highly regulated process of autophagy (37, 38).”
• Autophagy as a target for anticancer therapy (2011, background): “Finally, a retrieval pathway is required for the disassembly of Atg protein complexes from matured autophagosomes (mediated by Atg2, Atg9, and Atg18)”
• Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “A direct genetic link between autophagy and heart disease was suggested by studies of Danon disease, an X-linked cardiomyopa-Table thy that results from deficiency in LAMP-2, a transmembrane protein present in the late endosome and lysosome (39).”
• Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice (2005, background): “…J O U R N A L O F C E L L B IO L O G Y © The Rockefeller University Press $8.00 The Journal of Cell Biology, Vol. 169, No. 3, May 9, 2005 425–434 http://www.jcb.org/cgi/doi/10.1083/jcb.200412022 JCB: ARTICLE JCB 425 Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice”
• Cellular and molecular mechanisms of muscle atrophy (2013, background): “…autophagy, decreased muscle strength Chang et al., 2012 Lamp2 KO Accumulation of autophagic vesicles in many tissues, including skeletal muscles Tanaka et al., 2000 IGF1-Akt signaling pathway IGF1 Muscle-specific transgenic Muscle hypertrophy, protection against muscle loss during senescence,…”
• Role for Rab7 in maturation of late autophagic vacuoles (2004, background): “Recent results have shown that autophagy also contributes to cell homeostasis in muscle, liver and pancreas (Eskelinen et al., 2003; Tanaka et al., 2000), as well as to development, growth regulation, cancer and longevity (Liang et al.”
• Cell Death Signaling. (2015, background): “Additionally, two lysosomal proteins, LAMP1 and LAMP2, are required for the fusion process, and in their absence the autophagosome fails to fuse to lysosomes (Tanaka et al. 2000; Eskelinen et al. 2002, 2004).”