Identification and distinct regulation of yeast TATA box-containing genes.

By A. D. Basehoar, Sara J Zanton, B. Franklin Pugh. Cell, 2004

718 citations recorded by the source corpus.

Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of yeast genes contain a TATA box. Strikingly, TATA box-containing genes are associated with responses to stress, are highly regulated, and preferentially utilize SAGA rather than TFIID when compared to TATA-less promoters. Transcriptional regulation in yeast appears to be mechanistically bipolar, possibly reflecting a need to balance inducible stress-related responses with constitutive housekeeping functions.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d52823d4ebb2eaff370c38758b09852d41d958fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

The General Transcription Machinery and General Cofactors (2006, background): “It should be noted that although TFIID was initially defined as a TATA-binding factor by in vitro DNA-binding assays, yeast and human TFIID seem to act primarily through TATA-less promoters in vivo (Basehoar et al., 2004; Kim et al., 2005a).”
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. (2005, neutral): “Our analyses of these datasets reveal a clear negative correlation between Bdf1 occupancy and the presence of a consensus TATA-box in the promoter, whereas Spt3 occupancy is weakly positively correlated (Figures 3A and 3B; only 19% of yeast promoters are TATA containing ( Basehoar et al., 2004 ).”
Phenotypic consequences of promoter-mediated transcriptional noise. (2006, background): “cerevisiae have demonstrated that genes expressed from promoters containing highly conserved TATA box sequences are associated with stress response, in contrast to the larger number of ‘‘TATAless’’ promoters that function primarily in cellular ‘‘housekeeping’’ (Basehoar et al., 2004; Huisinga and Pu”
Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals (2008, background): “(E) The sequences of the Poly(dA:dT)-containing elements of (a–c) that we measured, along with their chromosomal locations. doi:10.1371/journal.pcbi.1000216.g008 PLoS Computational Biology | www.ploscompbiol.org 13 November 2008 | Volume 4 | Issue 11 | e1000216 lacking TATA elements and having nucle”
A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. (2008, background): “TATA-containing genes tended to have less of a canonical pattern, which may be related to their greater dependency on chromatin remodeling complexes than most other genes (Basehoar et al. 2004).”