Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

By T. Okada, Y. Fujiyoshi, M. Silow, Javier Navarro, E. Landau, Y. Shichida. Proceedings of the National Academy of Sciences of the United States of America, 2002

649 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d4ff51bc4f9b304760a38065f5dc1aab42b119f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Melittin: a Membrane-active Peptide with Diverse Functions (2007, background): “In addition, it has become increasingly evident that water molecules mediate lipid–protein interactions (Ho and Stubbs 1992; Essen et al. 1998; McAuley et al. 1999) and hence the function of membrane proteins (Sankararamakrishnan and Sansom, 1995; Okada et al. 2002; Kouyama et al. 2004).”
Structure of bovine rhodopsin in a trigonal crystal form. (2003, result): “Here we describe the refined structure of bovine rhodopsin in the trigonal crystal form, and compare it with previous structural reports of the tetragonal crystal form.(14,18,19) In addition, we relate the crystal structures to the membrane environment by docking them into a cryo-EM map(10) of 2D cr”
G protein coupled receptor structure and activation. (2007, background): “Three-dimensional crystals—More recently, three dimensional crystals structures of rhodopsin have been obtained by several groups [21–26].”
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. (2004, methodology): “Three-dimensional crystals of bovine rhodopsin were grown by hanging-drop, vapor-diffusion at 10 8C with conditions modified from previous studies.(8) Rhodopsin (6–8 mg/ml) purified in heptylthioglucoside micelles was mixed with a crystallization solution containing 6–12 mM b-mercaptoethanol, 0.”
Modern homology modeling of G-protein coupled receptors: which structural template to use? (2009, background): “…third crystal structure of Hs_Adrb2 bound to cholesterol and the partial inverse agonist timolol 17, as well as by a new crystal structure of rhodopsin from Todarodes pacificus (Tp_Rho) 18 , which exhibited extended TM helices 5 and 6 at the cytoplasmic side and a consequent reduced length for IL3.”