Survivin, cancer networks and pathway-directed drug discovery
By D. Altieri. Nature Reviews. Cancer, 2008
1,061 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/d4a68f5883654de956727b7f52eb0ec9b9ab34d0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Guido Kroemer
- L. Galluzzi
- Simone Fulda
- Oliver Kepp
- John Karanicolas
- David K. Johnson
- M. Castedo
- Ilio Vitale
In Oncology
- Guido Kroemer
- L. Galluzzi
- Oliver Kepp
- M. Castedo
- John Karanicolas
- David K. Johnson
- F. Greten
- Simone Fulda
Citations in the corpus
- Molecular mechanisms of cisplatin resistance (2012, background): “Spierings DC, de Vries EG, Vellenga E, de Jong S. (2003). Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line.”
- gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. (2009, background): “role of the small inhibitor of apoptosis (IAP) family protein survivin in counteracting apoptosis as well as controlling mitogenic progression ( Altieri, 2008 ) is likely to provide a functional explanation for some of our observations on cell-cycle protein expression.”
- Druggable Protein Interaction Sites Are More Predisposed to Surface Pocket Formation than the Rest of the Protein Surface (2013, background): “Survivin carries dual functions which together explain its important role in cancer: it serves as an inhibitor of apoptosis and is also required for cell division [40].”
- Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations (2015, neutral): “Survivin carries dual functions which together explain its important role in cancer: it serves as an inhibitor of apoptosis and is also required for cell division (62).”
- Tumor resistance to apoptosis (2009, background): “IAP family protein that controls also mitosis in addition to its role in the regulation of apoptosis.(77)”
- Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, background): “Conversely, inhibitors of mitotic catastrophe, like survivin, are often overexpressed or hyperactivate”