Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.

By C. Howell, T. Bestor, F. Ding, Keith E. Latham, C. Mertineit, J. Trasler, J. Chaillet. Cell, 2001

701 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/d49527f13b42eeb302d135d5de96b3384a82d6bc

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In Genetics

1. Wolf Reik
2. W. Dean
3. A. Bird
4. Jörn Walter
5. Fátima Santos
6. P. Hájková
7. S. Erhardt
8. Natasha Lane

In Molecular Biology

1. Wolf Reik
2. W. Dean
3. A. Bird
4. Jörn Walter
5. P. Hájková
6. Natasha Lane
7. Fátima Santos
8. S. Erhardt

In Pediatrics, Perinatology and Child Health

1. Wolf Reik
2. Jörn Walter
3. W. Dean
4. Fátima Santos
5. A. Bird
6. E. Li
7. Michael Joseph Meaney
8. S. Matesanz

Citations in the corpus

• Epigenetic reprogramming in mammals. (2005, background): “needed for the maintenance of imprinted methylation (53).”
• Epigenetic inheritance during the cell cycle (2009, background): “DNA demethylation of the maternal genome during pre-implantation development is thought to be passive and can be explained by the dilution of DNA methylation during replication, by preventing DNMT1 from functioning at the replication for”
• DNA methylation patterns and epigenetic memory. (2002, background): “Subsequent evidence, however, does not support a role for DNMT1 in de novo methylation in vivo (Lyko et al. 1999; Howell et al. 2001), and therefore the biological significance of its predilection for deformed DNA is uncertain.”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, background): “The likely reason for passive demethylation is that Dnmt1 protein is excluded from nuclei of cleavage embryos at most stages (Carlson et al., 1992; Howell et al., 2001).”
• Dynamic reprogramming of DNA methylation in the early mouse embryo. (2002, background): “Indeed, there is a critical requirement for the oocyte form of Dnmt1 to maintain methylation at imprinted loci (Howell et al., 2001).”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Fittingly, the maintenance methyltransferase DNMT1 shows very limited affinity to oxidized 5mC derivatives (Hashimoto et al. 2012) and is generally excluded from the nucleus of preimplantation embryos (Howell et al. 2001; Hirasawa et al. 2008).”