What is a resistance gene? Ranking risk in resistomes

By J. Martínez, Teresa M. Coque, F. Baquero. Nature Reviews Microbiology, 2014

908 citations recorded by the source corpus.

Subfields: Applied Microbiology and Biotechnology, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/d48197dd5b4298b26b3cc1c9f710674b98222453

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Citations in the corpus

Environmental factors influencing the development and spread of antibiotic resistance (2017, neutral): “In this paper, we follow the operational definition of resistance by Martinez, Coque and Baquero (2015), which postulates that a strain is resistant against an antibiotic if its minimal inhibitory concentration (MIC) is higher than for the corresponding parental wild-type strain.”
Antibiotic-Resistance Genes in Waste Water. (2017, background): “If an ARG is situated in a mobile genetic element (MGE) it is evaluated to possess an increased risk in the proposed risk analysis [9].”
MEGARes 2.0: a database for classification of antimicrobial drug, biocide and metal resistance determinants in metagenomic sequence data (2019, methodology): “While short-read metagenomic data is not always well-suited to co-localization analyses (51), users who wish to perform microbiome-resistome cooccurrence analysis can then use these count matrices as input into separate statistical analyses [see, e.”
The Rising Tide of Antimicrobial Resistance in Aquaculture: Sources, Sinks and Solutions (2017, background): “Sediments hold an active mix of bacterial communities, with evidence to suggest that they may be a substantial reservoir of faecal pathogens [66] and antimicrobials [67].”
MEGARes: an antimicrobial resistance database for high throughput sequencing (2016, background): “Furthermore, the definition of an AMR ‘gene’ varies between classes and is currently debated within the scientific community, leading to confusion about whether a SNP denotes a gene haplotype or a new gene (45).”
Multidrug evolutionary strategies to reverse antibiotic resistance (2016, neutral): “1016/0962-8479(95)90009-8; pmid: 7496004”