PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth*
By E. Rosen, B. Spiegelman. Journal of Biological Chemistry, 2001
1,107 citations recorded by the source corpus.
com-prise an important subfamily of the nuclear hormone receptor(NHR) superfamily. These ligand-activated transcription factorshave been intensively studied for more than a decade and havebeen implicated in such diverse pathways as lipid and glucosehomeostasis, control of cellular proliferation, and differentiation.The name PPAR derives from the initial cloning of one isoform asa target of various xenobiotic compounds that were observed toinduce proliferation of peroxisomes in the liver (1). This proteinwas called the peroxisome proliferator-activated receptor, nowknown as PPAR . Within a few years, the group of PPARs wasexpanded to include PPAR and PPAR (also referred to as PPAR ,NUC1, and FAAR) (2–6). This review will focus on PPAR .
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/d433b9d62e14dc4733a5e1354d2e06ca7f275ab0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
In Physiology
Citations in the corpus
- Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways (2004, background): “Activation of phenotype-specific transcription factors, such as osteoblastspecific Runx2/Cbfa1 and adipocyte-specific PPARγ 2, determines lineage commitment (Tontonoz et al ., 1994b; Ducy et al ., 1997; Komori et al ., 1997; Karsenty, 2001; Rosen & Spiegelman, 2001).”
- PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors (2004, positive): “Based on previous observations (16, 17, 22, 32, 33) and these results, it appears that C/EBP-β and C/EBP-δ lie upstream of PPARγ, while C/EBP-α is Figure 4 Radiological and histomorphometric analyses of OVX and sham-operated (Sham) female littermates of PPARγ+/– and WT genotypes.”
- Activation of PPARα and PPARγ by Environmental Phthalate Monoesters (2003, background): “PPAR regulates a broad range of physiological processes, including adipogenesis, fatty acid uptake, cell proliferation, and the formation of atherosclerotic plaques (Rosen and Spiegelman, 2000, 2001).”