A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP

By Christopher J. R. Loewen, A. Roy, T. Levine. EMBO Journal, 2003

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Molecular machinery for non-vesicular trafficking of ceramide (2003, background): “In addition, the MR domain of CERT contains a motif for targeting the E”
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. (2004, background): “Mutations in the yeast SCS2 affect phospholipid metabolism and disrupt the signaling pathway from the ER that regulates inositol biosynthesis and the unfolded protein stress response (Kagiwada et al. 1998; Loewen et al. 2003).”
Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide (2006, background): “A short peptide motif interacting with VAP proteins has recently been identified [37].”
A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. (2013, unknown): “On the other hand, the FFAT motif binds specifically the type II ER membrane protein VAP (Furuita et al., 2010; Kaiser et al., 2005; Loewen et al., 2003; Mikitova and Levine, 2012).”