Cyclical DNA methylation of a transcriptionally active promoter

By R. Métivier, Rozenn Gallais, C. Tiffoche, Christine Le Péron, R. Jurkowska, Richard P. Carmouche, David Ibberson, P. Baráth, F. Demay, G. Reid and 4 more. Nature, 2008

929 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d3fbc22fd6af0f7c57fa1f585ca7e5022776566f

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In Molecular Biology

1. Yi Zhang
2. Hao Wu
3. E. Nestler
4. K. Hochedlinger
5. F. Lubin
6. T. Roth
7. Kathrin Plath
8. J. Zierath

Citations in the corpus

• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “In vitro biochemical studies suggest that DNMT3A/3B can remove the hydroxymethyl group of 5hmC to generate unmodified cytosine in the absence of SAM and under oxidizing conditions (Chen et al., 2012; Liutkeviciute et al., 2009).”
• Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair (2011, neutral): “, 2000), or indirectly, by acting on G:T mismatches originated by a controlled deaminase activity of DNMT3a and DNMT3b (Metivier et al., 2008).”
• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “Alternatively, DNMTs have recently been discovered to be regulators of DNA demethylation as well as DNA methylation, and this mechanism might account for an effect of DNMT inhibition to affect both increases and decreases in DNA methylation (Kangaspeska et al., 2008; Métivier et al., 2008).”
• Epigenetic reprogramming and induced pluripotency (2009, background): “However, the nature and existence of demethylating enzymes in mammals remains highly controversial (Barreto et al., 2007; Bhattacharya et al., 1999; Hendrich et al., 2001; Jin et al., 2008; Kangaspeska et al., 2008; Metivier et al., 2008).”
• Rapid DNA methylation changes after exposure to traffic particles. (2009, background): “A previous study of 30 healthy volunteers reported cyclic variations in blood DNA methylation content observed over a 24hour period (36), and recent investigations have shown transient cyclical methylation and demethylation of specific gene promoters (37, 38).”
• Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens (2010, background): “Therefore, we next tested whether intra-NAc delivery of RG108, a potent, non-nucleoside inhibitor of DNA methylatio”
• Acute exercise remodels promoter methylation in human skeletal muscle. (2012, background): “DNA methyl transferases 3A and 3B (DNMT3A and DNMT3B, also called de novo methyl transferases) possess demethylase activity, but the biochemical sequence is unknown (Kangaspeska et al., 2008; Métivier et al., 2008).”
• DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 (2008, positive): “Evidence is accumulating for an active DNA demethylation process in vertebrates, including studies on the activation of the interleukin-2 locus (Bruniquel and Schwartz, 2003), active demethylation following fertilization ( Mayer et al., 2000; Oswald et al., 2000; Reik, 2007), and recent evidence fo”