Amygdala, Medial Prefrontal Cortex, and Hippocampal Function in PTSD

By Lisa M. Shin, Scott L. Rauch, R. Pitman. Annals of the New York Academy of Sciences, 2006

1,222 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/d3e0f4c57b4cd63ec0ee1d2a447bef25d960b65c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Gregory J. Quirk
2. Devin Mueller
3. Sonia J. Bishop
4. Thomas Elbert
5. M. Cloitre
6. Matthew P. Walker
7. Iris-Tatjana Kolassa
8. Andrea Goldstein

In Cognitive Neuroscience

1. Devin Mueller
2. Sonia J. Bishop
3. Gregory J. Quirk
4. Andrea Goldstein
5. Thomas Elbert
6. M. Cloitre
7. Anthony Charuvastra
8. H. Hart

In Developmental Neuroscience

1. Thomas Elbert
2. Devin Mueller
3. Matthew P. Walker
4. Sonia J. Bishop
5. Gregory J. Quirk

Citations in the corpus

• The Role of Sleep in Emotional Brain Function (2014, background): “…reported in several affective psychopathologies, including major depression, bipolar disorder, generalized anxiety disorder and PTSD (Davidson 2002, Drevets et al 2008, Etkin 2010, Etkin & Wager 2007, Nitschke et al 2009, Paulus & Stein 2006, Rauch et al 2000, Shin et al 2006, Siegle et al 2007).”
• Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “The hippocampus also shows decreased volume and activity in PTSD (Bremner, 2006; Shin et al, 2006; Gilbertson et al, 2002), consistent with the hypothesis that contextual modulation of extinction is compromised.”
• Neurocognitive mechanisms of anxiety: an integrative account. (2007, background): “function and/or structure, but the findings from these studies remain unclear [ 65 ,66].”
• Neuroimaging of child abuse: a critical review (2012, background): “The amygdala (see Figure 1) plays a key role in emotional processing, assessment of threatening information, behavioral regulation, fear conditioning, and memory for emotional events (Davis and Whalen, 2001; Shin et al., 2006; Dolan, 2007).”
• Structural and Functional Neuroplasticity in Relation to Traumatic Stress (2007, background): “The mPFC includes the anterior cingulate cortex (ACC), which is implicated in evaluating the emotional significance of stimuli and in attentional function (Cardinal, Parkinson, Hall & Everitt, 2002).”
• Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, neutral): “While it remains controversial whether anxiety disorders represent pathological manifestations of normal fear learning mechanisms (302, 312, 313, 383), there is consensus that the structures normally involved in such learning display abnormal activity patterns in anxious subjects (49, 467).”
• Social bonds and posttraumatic stress disorder. (2008, background): “…and numbing (Cahill 1997, Cahill et al. 2003, Frewen & Lanius 2006, Kazui et al. 2000, Pitman & Delahanty 2005, Quirk et al. 2006, Rauch et al. 2006, Rothbaum & Davis 2003, Shin et al. 2006), and the resolution of fear and various other associated emotions is critical to recovery from the disorder.”
• A Review of Adversity, The Amygdala and the Hippocampus: A Consideration of Developmental Timing (2009, neutral): “…events (e.g., combat, physical assault) and show that in adults the amygdala is both smaller (Driessen et al., 2000; Schmahl et al., 2003) and more reactive to emotional stimuli (Liberzon et al., 1999; Rauch et al., 2000; Shin et al., 2004; Armony et al., 2005; reviewed in Shin et al., 2006).”