TGF-β signaling: positive and negative effects on tumorigenesis

By L. Wakefield, A. Roberts. 2002

814 citations recorded by the source corpus.

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Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology (2006, background): “gov/cancertopics/types/breast/">breast cancer cells might become refractory to the growth-inhibitory effect of TGFβ, and that TGFβ, through its effect on the extracellular matrix, might promote invasion and metastasis in patients with advanced diseas”
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003, background): “Loss of TGF-β-induced suppression in cancer Given the antiproliferative and apoptotic functions of TGF-β, it is not surprising that this pathway is disrupted by somatic mutation in cance”
Molecular mechanisms of alcohol-mediated carcinogenesis (2007, background): “TGFβ1 can switch from an early tumour suppressor to a stimulator of growth and invasion during colon carcinoma progression, possibly based on its ability to regulate EM”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “This signalling pathway also inhibits proliferation of many carcinoma cells, at least in the early stages of tumorigenesi”
Smad3 as a mediator of the fibrotic response (2004, background): “In the initial stages of carcinogenesis, TGF-b is thought to have tumour suppressor functions (Wakefield & Roberts 2002).”