Reduced fear expression after lesions of the ventral hippocampus

By Kirsten G. Kjelstrup, F. A. Tuvnes, H. Steffenach, R. Murison, Edvard I. Moser, May-Britt Moser. Proceedings of the National Academy of Sciences of the United States of America, 2002

885 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/d365d095618a7f59b6c5a4e54f172200ad5eee2a

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Citations in the corpus

Using immediate-early genes to map hippocampal subregional functions. (2007, background): “On the other hand, ventral, but not dorsal, lesions attenuated unconditioned fear (Kjelstrup et al. 2002), various measures of anxiety (Bannerman et al.”
Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus (2013, background): “Selective lesion studies showed that removal of the dorsal hippocampus disrupted spatial memory, while lesion of the ventral pole spared spatial learning but had an anxiolytic effect (Bannerman et al., 1999, 2002; Kjelstrup et al., 2002; Moser et al., 1995; Richmond et al., 1999).”
Regional dissociations within the hippocampus--memory and anxiety. (2004, background): “A similar observation was made by Kjelstrup and colleagues who reported that both complete and ventral hippocampal lesions reduced defaecation scores relative to sham and dorsal hippocampal lesioned animals following confinement in a brightly lit white chamber [70].”
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety (2010, positive): “mPFC and vHPC in Anxiety Previous work has shown that lesions of the vHPC (Bannerman et al., 2004; Kjelstrup et al., 2002) or mPFC (Gonzalez et al.”
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (2007, background): “The rodent homologue of the anterior hippocampus in humans has also been shown to play a role in endogenous anxiety (80, 81).”
Functional Dissociation of Adult-Born Neurons Along the Dorsoventral Axis of the Dentate Gyrus (2014, background): “Indeed, ablation of adult hippocampal neurogenesis has been shown to alter the overall network circuitry of mature granule cells in the dentate gyrus (Lacefield et al., 2012; Burghardt et al., 2012).”
Alcohol: Effects on Neurobehavioral Functions and the Brain (2007, background): “The anatomy of the hippocampus is closely associated with subcortical structures, which contribute to the hypothalamic–pituitary– adrenal axis (Kjelstrup et al. 2002).”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, neutral): “…the predominant view is that the dorsal hippocampus is particularly critical for spatial learning, whereas the ventral hippocampus is involved in regulating fear and anxiety (Moser et al., 1995; Kjelstrup et al., 2002; Bannerman et al., 2004; Pothuizen et al., 2004; Pentkowski et al., 2006).”