Role of NF-κB in p53-mediated programmed cell death

By K. Ryan, M. Ernst, N. Rice, Karen H. Vousden. Nature, 2000

739 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d34e8a29b0a48b0966a00b62883aba01d0accbd5

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Citations in the corpus

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. (2011, result): “Despite these well-established links, some studies suggest that NF-kB can promote rather than suppress apoptosis, suggesting it might have tumor-suppressive activity (Ryan et al. 2000).”
Non-cell-autonomous tumor suppression by p53 (2013, background): “As has been observed in other contexts (Ryan et al., 2000), p53 triggered NF-kB activation as assessed by the nuclear accumulation of the NF-kB subunit p65 (Figures 6B and S6A).”
A crucial role for adipose tissue p53 in the regulation of insulin resistance (2009, result): “In agreement with previous reports that induction of p53 causes activation of NF-κ”
Cellular response to oxidative stress: Signaling for suicide and survival * (2002, background): “In addition, the finding that p53-mediated cell death depends on NFkB supports such a pro-apoptotic function (Ryan et al., 2000).”
Update on adenovirus and its vectors. (2000, background): “It has been claimed that adenovirus infection, especially at high multiplicities, can lead to the activation of NF-κB at early stages of infection (Clesham et al., 1998 ; Lieber et al., 1998).”
Live or let die: the cell's response to p53 (2002, background): “76 ), other studies have shown a requirement for NF-κB in p53-mediated cell deat”
Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “Moreover, in some circumstances RelA and p53 cooperatively induce apoptosi”
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “One such study published a few years ago concluded that tumor suppressor p53 activates NF-kB via MEK1 and pp90rsk, and that NF-kB plays a vital role in p53-mediated apoptosis (Ryan et al., 2000).”
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation (2008, background): “These findings indicate that p53 suppresses NF-κB activation and regulates oncogene-induced transformation; however this remains controversia”